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CLINICAL-RESEARCH-MANAGEMENT5 MIN READ

Protect Database Lock With Critical Path Thinking

Use critical-path thinking to identify the work that can actually delay database lock.

Not every open task can delay lock, even if every task has an owner asking for attention. Find the dependent chain: external data reconciliation -> medical review -> data signoff -> lock. Then protect the task that controls the finish date. List dependencies Find the controlling task Choose escalation Apply to a fresh lock plan Step 1: map the dependency chain The team lists central lab reconciliation, adverse-event coding, dashboard refresh, medical review, and final lock approval. Critical path begins with dependency logic, not priority labels. Step 2: find the controlling task Central lab reconciliation must finish before medical review…

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