Distinguish gene-disease validity from clinical actionability.
The product claim A report wants to mark a gene as actionable because papers connect it to a disease. Users may change screening, medication, or anxiety level based on the word actionable. Two questions Validity before actionability ClinGen separates the strength of evidence for a gene-disease pair from the separate question of whether clinical action is supported. gene associated Not enough for action Responsible recommendation Causation evidence and action evidence are related, not identical. 01 Validity 02 Variant 03 Action Check the gene-disease claim Step 1
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