See why randomization and blinding exist

The point of bias control is to make the comparison believable. Randomization protects allocation Without randomization, teams may consciously or unconsciously assign healthier, sicker, more adherent, or more hopeful participants to one arm. That makes the groups different before treatment even begins. Randomization uses chance to reduce that imbalance. Comparators give change a reference point A participant may improve because of the investigational product, standard care, natural disease fluctuation, attention from the study team, or measurement variation. A comparison group helps separate the treatment signal from those background forces. Blinding protects behavior and assessment If participants or staff know the…

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